April 14, 2010 Dinner/Seminar

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Recent developments in separation solutions from Tosoh Bioscience: a look into reversed phase and HILIC chromatography.

Atis Chakrabarti
Tosoh Bioscience

Abstract
Tosoh Bioscience offers 16 distinct Reversed Phase column types (silica or methacrylate) particles for the analysis of a wide variety of compounds, ranging from neutral polar and non-polar solutes to acidic, basic, and amphoteric compounds. Tosoh offers a number of HILIC columns for the separation of highly polar compounds which are not retained in reversed phase. This presentation is about an overview of the separation solutions available for different application needs.

Bio.
Atis Chakrabarti earned a Ph.D. in Chemistry from North Bengal University, India on the design and synthesis of anti-proliferative probes.  His post doctoral research at the Indian Institute of Science, Bangalore, India, focused on the molecular biology and biophysical characterization of bacterial thioredoxin. In 2000, he joined Thomas Jefferson Medical College and University in Philadelphia,  researching diagnostic and therapeutic probes for PET imaging of pancreatic cancer. Throughout his career he used a wide variety of types of chromatography for the purification of these probes. He is an adjunct faculty member in the department of chemistry at Camden County College, NJ.  His most recent position at Apex Pharmaceuticals, NJ included analyzing, by chromatographic techniques, API's for bulk and dosage use. Atis joined Tosoh Bioscience in July 2008 and is currently an active member of Technical Service team. In his leisure time Atis enjoys spending time with his family, traveling, and camping.



Accurate, High Resolution Analysis of Small Molecule Impurities, Drug Metabolites, and Industrial Chemicals Biosketch

Sandy Yates
Bruker Daltonics

Abstract
The metrics for accurate analytical analysis of small molecules in a variety of applications in pharmaceutical and industrial settings are constantly being advanced.  Regulatory and economic requirements are often key drivers of these changes.  In some cases, the traditional methods of analytical detection using slow or low resolution mass spectrometry are becoming obsolete due to the requirement of increased demands on compound and product analyses.  In addition, new fast chromatographic methods are becoming a necessity.
 
A number of small molecule analysis challenges will be presented.  A mixture of a series of 10 small molecule drug compounds will be simultaneously analyzed by fast chromatography and high performance mass spectrometry.  Detail on how the molecular formulae of all 10 compounds were successfully and accurately identified, including compounds which have not been chromatographically resolved.

Bio.
Sandy Yates, PhD, is currently a product specialist with Bruker Daltonics, Billerica, Massachusetts. USA.  His current area of specialization is small molecule analysis using high resolution mass spectrometry in combination with rapid separation liquid chromatography.  Sandy holds a degree in chemistry with mathematics (Heriot-Watt University, UK).  Prior to joining Bruker Daltonics, Sandy managed a mass spectrometry core facility at Rice University, Houston.  Sandy's experience with high resolution mass spectrometry began over ten years ago with Fourier transform ion cyclotron resonance mass spectrometry.  Firstly at the University of Edinburgh, UK, followed by a period of several years at the University of Manchester (formerly UMIST), UK, with Professor Simon J Gaskell.