North Jersey Chromatography Group
Princeton University
administ
November NJCG Dinner/Seminar
November 12, 2018
Registration:
The cost is FREE for all attendees!
Princeton University
Frick Chemistry Laboratory
Princeton Lot 21, 47 Faculty Road
Princeton NJ 08540
Switching Solvents: A Research Journey from LC to SFC
James P. Grinias and Gustavo Moura-Letts
Rowan University Department of Chemistry & Biochemistry
Abstract: This presentation will describe our work managing the transition from LC to SFC for the analysis of new chiral synthetic products by a collaborative research team at Rowan University. As researchers, the authors were both extensive users of standard HPLC and UHPLC methodology, but many new insights were gained as the new world of SFC was explored. This talk will highlight many of key observations that others making this transition might want to consider, including topics such as column and solvent selection, instrument operation and maintenance, and general method development strategies. Further, early results in method development towards monitoring the chiral directed synthesis of N,N-, N,O-, N,S-containing small (three- or four-member) heterocyclic scaffolds will be shown. This work has proved relevant towards further synthesis of novel pharmaceutical products.
Implementation of a Novel Shimadzu Supercritical Fluid Chromatography Screening Platform to Support Drug Discovery Purification
Shuping Dong, William Leister
Discovery Analytical, PTS, GlaxoSmithKline
1250 S Collegeville Rd, Collegeville, PA 19426
Abstract
Supercritical fluid chromatography (SFC) is a useful tool for medicinal chemistry purification. More and more early discovery compound purification requires the use of SFC, especially for chiral/isomer separation. To accommodate this increased workload an advanced SFC screening system was needed to handle lager numbers of samples. Desirable system attributes include sample multiplexing, robustness, reduced footprint and ease of operation. A first of its kind Shimadzu SFC Screening System, built on the Nexera UC base, has exceeded our increasing demands for high throughput screening.
Princeton University
administ